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Methotrexate (MTX) is a cornerstone drug in the treatment of RA, primarily functioning through multiple mechanisms: inhibiting the production of pro-inflammatory cytokines, modulating the Th1/Th2 balance, and suppressing the proliferation of immune cells like T and B cells

However, other research has turned up mixed results, indicating a need for additional studies in the future

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Fischer (ARCF) inhibits the serum inflammatory cytokines expression, like TNF-, IL-6, IL-1, IL-33, and RF (60)

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